Mediastinal Mass as a Prognostic Factor of Hodgkin Lymphoma – Case Review

Many studies have researched the prognostic factors of Hodgkin disease. Up date, seven most important prognostic factors have been defined. Among them, as an important negative prognostic factor, the dissemination of the disease at the moment of diagnosis stands out. The aim of this study was to determine the influence of the presence of mediastinal mass greater than a third of the chest diameter in Hodgkin lymphoma on the disease outcome. In this study, an 18-year-old patient P.A. was presented. At the time of diagnosis, the patient had Bulky disease. Mediastinal mass was observed by radiography, computed tomography, ultrasound of the heart. The patient was treated with ABVD, GDP, BEACOPP, miniBEAM protocol and mediastinal radiation. In this patient, the mediastinal mass persisted in spite of the therapy. The course of disease deteriorated due to the presence of resistant pericardial effusion, and the patient died three years after. Acta Medica Medianae 2008;47(4):25-28.